【摘要】 ＲＢ１０１［Ｈ２Ｎ－ＣＨ－（ＣＨ２－Ｓ－ＣＨ３）－ＣＨ２－Ｓ－Ｓ－ＣＨ２－ＣＨ（ＣＨ２φ）－ＣＯＮＨ－ＣＨ－（ＣＨ２φ）－ＣＯＯＣＨ２φ）］是一种新型的可透过血脑屏障、对脑啡肽酶及氨基肽酶均有抑制作用的混合型脑啡肽降解酶抑制剂。采用大鼠尾静脉给药途径，观察不同剂量的ＲＢ１０１对低频及高频电针作用的影响。结果表明，ＲＢ１０１可以加强低频（２Ｈｚ）电针的镇痛效果，并呈剂量效应关系，而对高频（１００Ｈｚ）电针的镇痛作用没有影响。更多还原

【Abstract】 RB101[H2N-CH-(CH2-S-CH3)-CH2-S-S-CH2-CH(CH2) CONH-CH-(CH2φ)-COOCH2φ)] is a newly discovered mixed enkephalin degrading enzyme inhibitor,which could penetrate blood-brain-barrier and plays an important role in suppressing the activities enkaphalinase and aminopeptidase thus prolonging the survival of enkephalins in the central nervous system.The effect of RB101 on low and high frequency electroacupuncture was observed.The results showed that intravenous injection of RB101 to the rat produced a significant enhancement of 2Hz electroacupuncture-indUced analgesia in a dose-related manner, but had no effect on 100Hz electroacupuncture analgesia.更多还原