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儿童反复呼吸道感染与细菌多糖抗原特异性IgG亚类抗体缺陷

RECURRENT RESPIRATORY TRACT INFECTIONS AND DEFICIENCIES OF BACTERIAL POLYSACCHARRIDE ANTIGEN SPECIFIC IgG SUBCLASS ANTIBODIES.

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【作者】 陈实杨锡强李成荣沈锦

【Author】 Chen Shi,et al.Children Hospital)

【机构】 深圳市南山医院儿科

【摘要】 采用酶联免疫吸附法在157例反复呼吸道感染(RRTI)儿童中检测出血清IgG_2缺陷15例;同时发现肺炎球菌多糖抗原(PnPg)特异性IgG_2抗体缺陷26例,其中9例同时伴血清IgG_2缺陷,占15例血清IgG_2缺陷者的60%;脑膜炎球菌多糖抗原(MPs)特异性IgG_2抗体缺陷20例,其中11例同时伴血清IgG_2缺陷。占15例血清IgG_2缺陷者的73%。本文提示:血清多糖抗原特异性IgG亚类抗体缺陷是儿童RRTI的重要原因之一;血清IgG_2正常并不能排除多糖抗原特异性IgG_2抗体缺陷。

【Abstract】 ith enzyme. linked immunosorbent assay,serum IgG2 deficiencies were found in 15 out of 157cases of children with recurrent respiratory tract infections (RRTI),Manwhile,deficincies ofPDeumoccocal polysaccharride(PnPs) and meni ngoccocal palysaccharride(MPs) antigen specificIgG2 amtibodies were also found in 23 and 20 cases respectively.Deficiencies of PnPs and MPsspecific IgG2 antibodies were complicated with 9 and 11 cases respecti vely of serum IgG2antibodies were coincided in 15 cases The results suggested that the decreased palysaccharridespecific IgG2 andtibody be one of the important causes of RRTI in children.The possiblity of polysaccharride antigen specific IgG2 defects can not be excluded with narmal serum IgG2.

【基金】 国家自然科学基金,四川省卫生厅科研
  • 【分类号】R725.603
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