【摘要】 测定了水貂肠炎病毒无血清细胞培养灭活矿油疫苗和铝胶疫苗免疫接种水貂、豚鼠和家兔曲血清HI和SN抗体消长规律,证明豚鼠、家兔或水貂接种疫苗后11～40d的血清HI抗体水平是检定MEV矿油疫苗或铝胶疫苗对水貂的体液免疫力和免疫保护率的经济、简便、可靠的指标,从而建立了MEV疫苗免疫实验动物效力的检定指标——豚鼠、家兔或水貂注苗后11～40d的血清HI抗体应答水平,以及可取代该动物用作检定MEV疫苗免疫水貂的体液免疫力和免疫保护率的实验动物模型——豚鼠、家兔。更多还原

【Abstract】 The growth and decline laws of the immune serum haemagglutination-inhi-bition (HI) and serum-neutralizing(SN) antibodies levels for minks, guinea pigs and rabbits following inoculation with the inactivated vaccines from serum-free cell cultures of mink enteritis parvovirus (MEV) with mineral oil or Al(OH)3 gel adjuvant have been determined by the tests of statistical analyses. It has been proved by statistical analyses that the levels of HI antibody response of guinea pigs, rabbits or minks determined during 11-40 days post-vaccination (P. V. ) were reliable indexes for monitoring the humoral immune efficiency and immune protective rate of the MEV vaccines with mineral oil or Al (OH)3 gel adjuvant for minks, thus providing some economic, simple and scientific new indexes (Serum HI antibodies levels of guinea pigs, rabbits or minks determined during 11 -40 days P. V. ) and laboratory animal models (Guinea pigs or rabbits instead of minks) for monitoring the immune efficiency of MEV vaccines in large scale.更多还原