【摘要】 本文应用石蜡切片免疫组化ＰＡＰ法，回顾性观察了６１例直肠中分化管状腺癌组织ＥＲ、ＰＲ表达情况。ＥＲ（＋）／ＰＲ（＋）为４２．６％；ＥＲ（－）／ＰＲ（－）为５７．４％。ＥＲ／ＰＲ的存在表明该癌组织具有了依赖性激素的特性。ＥＲ（＋）／ＰＲ（＋）者的中位生存期为４．５年，一、三、五年生存率为８８．５％、５３．９％、３８．５％，均高于ＥＲ（－）／ＰＲ（－）者的生存率。　ＥＲ（－）／ＰＲ（－）者的中位生存期为２．４年，一、三、五年生存率为６５．７％、４２．８％、２８．６％。表达阳性与阴性两者的生存期有明显差异（Ｐ＜０．０１）。检测ＥＲ／ＰＲ受体亦可做为判定预后的指标之一。本实验证实ＥＲ、ＰＲ表达与年龄、性别以及ＬＮＭ之间无明显差异（Ｐ＞０．０５）。更多还原

【Abstract】 Expression of ER and PR in 61 cases with rectal middle differentiated adenocarcinoma were abserved by immunohistochemistry PAP method on paraffin section. The positive or negative rate of ER/PR were 42. 6% (26/61) or 57. 4% (35/61). The existance of ER/PR indicated that rectal cancernoma tissues possessedthe characteristic of depending upon sexhormone. The middle survival time of ER(+)/PR(+) or ER(-)/PR(-) was 4. 5-year time or 2. 5-year time. The 1,3, 5year survival rate of ER(+)/PR (+)(88. 5 %, 53. 9%, 38. 5%) were significantlyhigher than that of ER (-)/PR (-) (67. 5%, 42. 8%, 28. 6% ) (P<0. 01). It isconcluded that the expression ER/PR for rectal cancer patients may be consideredas one of the indicators in the prognosis but in age, sex and LNM.更多还原