【摘要】 乙酰吉他霉素对临床分离的革兰氏阳性球菌有较好的抑菌活力，其对金葡球菌、β－溶血性链球菌、表葡球菌的ＭＩＣ_５０分别为１、０．２２和４ｍｇ／Ｌ，对耐红霉素、青霉素的金葡球菌、表葡球菌半数以上较敏感，与吉他霉素相似，但其对革兰氏阴性菌无明显作用。乙酰吉他霉素对小鼠实验性细菌感染有明显保护作用。对金葡球菌、肺炎双球菌感染小鼠口服用药的ＥＤ_５０分别为７９．６和２５．１ｍｇ／ｋｇ。其疗效与吉他霉素、麦白霉素、乙酰螺旋霉素相似。乙酰吉他霉素小鼠１次口服的ＬＤ_５０＞１５ｇ／ｋｇ，与吉他霉素相比毒性无差异。更多还原

【Abstract】 Acetylkitasamycin has a strong antibacterial activity against Gram-positive bacteria,especially against Gram-positive coccus. The MIC₅₀ of acetylkitasamycin were 0.39mg/L against Staphylococcus aureus,0. 22mg/L against β-hemolytic Streptococcus, 4mg/L against Staphylococcus epidermidis. Its activity was the same as kitasamycin but stronger than mileumycin and acetylspiramycin.It was susceptible to erythromycin -resistant Staphylococus aureus and Staphylococcus epidermidis.It has no effects on Gram-negative bacteris.The protective effects of acetylkitasamycin against systemic infection in mice were as good as kitasamycin, meleumycin, and acetylspiramycin. The ED₅₀ of acetylkitasamycin against Staphylococcus-32 and Pneumococcus 31001-18 were 79. 6 and 25. 1 mg/kg respectively. The LD₅₀ values of acetylkitasamycin in mice were 15g/kg（op） and 2g/kg（ip）respectively.更多还原