【摘要】 用常规诱变育种方法对西索米星小单孢菌进行诱变育种，获得ＮＳ８－３０菌株，结合发酵条件研究，发酵效价比原始菌株提高１７倍以上，并在中试生产中应用。获得１株阻断型突变株７－２５，其代谢产物经光谱学分析鉴定为ＪＩ－２０Ａ，并对其代谢途径进行了讨论。更多还原

【Abstract】 Sisomicin high producer NS8-30 was isolated by conventional mutation breeding. As a result.the production of strain NS8-30 was increased by more than 17-fold,and was investigated in 5-ton fermentor.The blocked mutant 7-25 was obtained. By separating and purifying with IRC-50, antibiotic 7-25 was obtained as major component.It indicates that antibiotic 7-25 is identical with JI-20A by spectroscopy analysis.更多还原