【摘要】 31只大鼠行胸主动脉内皮剥脱术,随机分为对照组10只、雷公藤多甙组10只(9.4 mg/kg/d)和藻酸双酯钠组11只(30mg/kg/d).后两组于术前6天开始喂药.于术后14天观察各组大鼠胸主动脉新生内膜面积、内膜与中膜面积比、新生内膜覆盖率、~3H-TdR参入量.证明雷公藤多甙能显著抑制受损动脉内膜增生(P<0.001),而藻酸双酯钠则无此作用.更多还原

【Abstract】 31 rat were divided randomly into control group (n=10),tripterygium wilfordii glycosides group (n = 10 9. 4 mg/kg per day),and poly saccharide sulphate group (n=11. 30 mg/per day). We made balloon endothelium denudation in thoracic aortae of the rats. The treatments with drugs began 6 days before balloon injury and continously until the animal were killed 14 day after balloon injury. The determinations for area of neointima, neointima /media, coverage of neointima and 3H-TdR incoperation of thoracic aortae suggested that tripterygium wilfordii glycosides can inhibit intimal proliferation of injuried aorta, whill poly saccharide sulphate shows no effect.更多还原