【摘要】 为了解ＭＡＣ预处理方案的相关毒性──对性腺内分泌功能的影响，观察了１９例白血病患者用ＭＡＣ方案预处理行自体骨髓移植前后的垂体－性腺内分泌功能。所有患者移植前血清卵泡刺激素（ＦＳＨ）、黄体生成素（ＬＨ）、催乳素（ＰＲＬ）、睾酮（Ｔ）和雌二醇（Ｅ２）水平与正常对照组无明显差异（Ｐ＞０．０５）。女性在移植后１～１２个月血清ＦＳＨ和ＬＨ较移植前明显升高（Ｐ＜０．０１），血清Ｅ２水平较移植前明显降低（Ｐ＜０．０１），移植后１年内均有不同程度的闭经；男性在移植后１～１２个月血清ＦＳＨ较移植前明显增高（Ｐ＜０．０１），血清ＬＨ和Ｔ虽在正常值范围，但与移植前比较仍有统计学差异（Ｐ＜０．０５）。所有患者移植后１个月后血清ＰＲＬ水平与移植前均无显著差异（Ｐ＞０．０５）。６３．６％男性血清ＦＳＨ水平和６６．７％女性血清ＦＳＨ、ＬＨ及Ｅ２水平在移植后１年内逐渐恢复正常。研究结果表明，ＭＡＣ方案预处理自体骨髓移植后，患者性腺受到了一定程度损害，但多数患者可在近期内恢复，不影响长期存活者的生活质量。更多还原

【Abstract】 To investigate the toxicities associated with melphalan,Ara-C and cyclophosphamide(MAC)conditioning regimen,pituitary-gonadal endocrine function was studied in 19 patients with acute leukemia before and after autologous bone marrow transplantation(ABMT)with MAC conditioning.Before ABMT,the serum follicle stimulating hormone(FSH),luteinizing hormone(LH),prolactin(pRL),testosterone(T)and estradiol(E2)levels showed no difference from controls(P>0.05).At one to twelve months post-transplant,the serum FSH and LH levels were higher(p<0.01)and the E2 levels were lower than those pre-transplant(P<0.01)in all female patients,while the serum FSH levels were higher than those pre-transplant(P<0.01),and the LH and T concentrations were in normal range in the male patients.All women were amenorrhea within one year after ABMT.The PRL levels in all patients at one year post-transplant showed no difference from those at pre─transplant(P>0.05).The FSH,LH and E2levels in 66.7% of women and the FSH levels in 63.2%of men recovered at one year after ABMT.The results showed that,after ABMT with MAC preparative regimen,the gonadal of patient was impaired,but recovery could occur in a short period更多还原