【摘要】 作者使用高效液相色谱检测了肝硬变门静脉高压症患者（３８例）、原发性高血压患者（２４例）和对照病人（３４例）周围静脉血及上腔静脉、周围动脉、门静脉血肾上腺素和去甲肾上腺素浓度。肝硬变组及原发性高血压组患者周围血肾上腺素浓度分别为５７．５±３７．４ｐｇ／ｍｌ和５４．９±３９．９ｐｇ／ｍｌ，差异无显著意义，但与对照组（２３．５±１１．２ｐｇ／ｍｌ）相比浓度均有显著升高（Ｐ＜０．０１）。肝硬变组及原发性高血压组患者周围血去甲肾上腺素浓度分别为４５１．１±３８１．２ｐｇ／ｍｌ和５２４．３±２１ｐｇ／ｍｌ，与对照组相比（１８３．０±８３．３ｐｇ／ｍｌ）差异有极显著意义（Ｐ＜０．０１）。术中取上腔静脉、动脉和门静脉血分别比较肾上腺素和去甲肾上腺素浓度，除上腔静脉血肾上腺素浓度的差异有显著意义外（８３．７±４６．７ｐｇ／ｍｌ与２０７．２±５５．４ｐｇ／ｍｌ，Ｐ＜０．０５），其余差异均无显著意义。本研究结果表明肝硬变门静脉高压症患者存在着明显的儿茶酚胺类递质的代谢紊乱，其对患者全身及内脏血流动力学的影响与门静脉高压症发生发展的关系值得深入研究。更多还原

【Abstract】 HighPressureLiquidchromatographywasusedtomeasureserumadrenaline(E)andnoradrenaline(NE)concentrationsin38portalhypertensivepatients,28idiopathichypertensivepa-tients,and34controls,respectively.ItwasfoundthatperipheralEinportalhypertensivepatientsandcontrolswas57.5±37.4pg/mland23.5±11.2pg/mlrespectively(P<0.01),andperipheralNEwas451.1±381.2pg/mland183.0±83.3pg/ml(P<0.01).Comparedwithcontrols,peripheralEandNEinidiopathichypertensivepatientswerealsosignificantlyincreased(54.9±39.9pg/mlvs.23.6±11.2pg/ml,P<0.01,and524.3±219.9pg/mlvs.183.0±83.3pg/ml,P<0.01).EandNEinsupe-riorvenacava(SVC),portalvein,andperipheralarteryinportalhypertensivepatientswerealsoin-creased,butonlytheelevationofEinSVCwassignificant(207.2±55.4pg/mlvs.83.7±46.7pg/ml,P<0.05).OurresultsrevealsignificantmetabolicdisordersofEandNEinportalhypertensivepatients,whichmayplayanimportantroleinthepathogenesisofportalhypertension.更多还原