【摘要】 探讨卵磷脂胆固醇酰基转移酶（ＬＣＡＴ）活性下降是否肾病性高血脂血症的病因之一，以及舒降之与ＬＣＡＴ的关系。方法观察正常鼠、肾病鼠及舒降之治疗肾病鼠前后血脂指标及ＬＣＡＴ活性（摩尔酯化率ＭＥＲ及酯化分数ＦＥＲ）变化。结果肾病组的ＭＥＲ比正常对照组显著升高，而ＦＥＲ则显著降低。舒降之治疗后的各项血脂指标均显著改善，而ＬＣＡＴ的ＦＥＲ显著升高。结论肾病性高脂血症的ＬＣＡＴ活性下降是高胆固醇的结果而非其病因之一。舒降之降低高血脂导致ＬＣＡＴ活性继发性升高，而非通过提高ＬＣＡＴ活性而达到治疗效果。更多还原

【Abstract】 bjectiveToinvestigatetherelationshipbetweenLCATandsimvastatinandwhetherthedecreasingofLCATactivitywasoneofthepathogenicfactorsofnephrosishyperlipidemia.MethodsLCATactivity(MER,FER)wasdetectedinnormalcontrolrats、nephrosisratsandsimvastatintreatingrats.ResultsMERincreasedsignificantlybutFERdecreasedsignificantlyinnephrosisgroupthanthatinnormalgroup.LipidemiaindexesweresignificantlyimprovedandLCATactivity-FERincreasedsignificantlyaftersimvastatintreatment.ConclusionThedecreasingofLCATactivitywastheresultbutnotoneofthepathogenicfactorsofnephrosishyperlipidemia.SimvastatincanimprovethehyperlipidemiabutnotbytheenhancingtheLCATactivity,justleadingtoase-condaryefect.更多还原