【摘要】 探讨糖皮质不同激素剂量的给药方式及累积量对骨组织的影响。方法按配伍组设计，将３０只大白兔分为不同激素剂量的治疗组，并测定血清钙、磷、碱性磷酸酶、氨基端甲状旁腺素及骨密度。结果糖皮质激素性骨质疏松症与激素的剂量有关，发病机理涉及继发性甲状旁腺功能亢进，补充钙剂、维生素Ｄ具有预防及治疗作用。结论为减少糖皮质激素性骨质疏松症的发生，在临床上应给予激素最低的有效治疗剂量，并辅以钙剂、维生素Ｄ更多还原

【Abstract】 bjectiveTostudytheefectofvariantadministrativeandcumulativedoseofglucocorticoidontheskeleton.MethodsThirtymalerabbitsweredividedinto5groups.Serumcalcium、phosphorus、alkalinephosphatase、N-terminalfragmentofparathyroidhormoneandbonedensityweredeterminedbeforeandafterthetreatment.Re┐sultsGlucocorticoid-inducedosteoporosiswasassociatedwiththesteroiddose,thepathogenesiswasconcernedwiththedevelopmentofsecondaryhyperparathyroidism.SupplementationofcalciumandvitaminDwasaneffec-tivemethodforthepreventionandtreatment.ConclusionInordertoreducetheoccurrenceofglucocorticoid-in-ducedosteoporosis,itisnecessarytousethelowestefectivesteroiddoseandtosupplementcalciumandvitaminD.更多还原