【摘要】 通过测定保存不同时间后未移植胰腺组织内6-酮-前列腺素F_1α(6-keto-PGF_1α)及血栓素B₂（TXB₂）含量,对川芎嗪改善胰腺保存效果的作用机制作出初步探讨。6-keto-PGF_1α及TXB₂测定结果显示:加川芎嗪对6-keto-PGF_1α无明显影响,对TXB₂则能显著性降低,6-keto-PGF_1α:TXB₂的比值在加川芎嗪组最大,认为川芎嗪主要通过抑制TXA₂合成,升高PGI₂:TXA₂的比值,发挥PGI₂的保护作用,抑制TXA₂合成,就保护了内皮细胞,保证了器官再灌注时有充足的血供,使保存导致的实质细胞损伤易修复,从而达到一定程度的改善器官保存作用,这可能是川芎嗪改善器官保存的主要机理之一。更多还原

【Abstract】 In order to study the mechanism of ligustrazine in improving rat pancreas preservation, 6-keto-PGF_1α and TXB₂ level of pancreas tissues that had been preserved for various time were examined. The result showed that ligustrazine had no obvious effect on 6-keto-PGF_1α, but could obviously reduce TXB₂ level and increase the radio of 6-keto PGF_1α to TXB₂ suggesting that ligustrazine improved preservation mainly through inhibiting TXA₂ production, and increasing the radio of PGI₂ to TXA₂, thereby protecting the endothelium. These effects could ensure adequate blood supply, which facilitated the repair of injured parenchymal cells.更多还原