【摘要】 采用链亲合素—生物素化过氧化物酶法(LSAB)免疫组化法,辅以电镜,观察感染血吸虫尾蚴6、8周小鼠肝脏肿瘤坏死子因子α的表达及分布。结果表明,虫卵周围及肝窦壁均有TNFα阳性反应物,伴炎性细胞聚积及肝窦损伤。结果提示:TNFα可能是引起血吸虫病时肝内炎症与免疫反应的细胞因子之一。更多还原

【Abstract】 The authors observed the expression and localization of TNFα in liver of mice with acute schistosoma infection at 6th, 8th weeks by using immunohistochemical technique and electron microscopy. Immunostaining for TNFα was found in the areas surrounding ova and in hepatic sinusoids, accompanying with aggregation of inflammatory cells and damage to hepatic sinusoids. The results showed that TNFα could be a cytokine which contributes to inflammatory and immunologic reaction in schistosoma-infected liver.更多还原