【摘要】 应用ＤＮＡ凝胶电冰、电镜观察和流式细胞仪分析，对加热诱导Ｇ４２２胶质瘤程序性细胞死亡的作用进行了研究。结果表明，对脑荷Ｇ４２２胶质瘤鼠加热处理，可以诱导胶质瘤程序性细胞死亡，并与加热的剂量（温度×时间）和加热后恢复的时间有关。４５℃３０分钟的加热剂量诱导作用最强，高峰时间在加热后２～１２小时。文中对加热诱导胶质瘤程序性细胞死亡的意义作了讨论。更多还原

【Abstract】 Using DNA gel electrophoresis, electron microscopic examination and flow cytometric analysis,program cell death induced by hyperthermia in mouse G422 glioma in vivo was studied.The result showed hyperthermia could induce program cell death in mouse G422 glioma. Program cell death was related to heating dose(temperature×time)and recovery time from hyperthermia.There was strongest effect on program cell death at 45℃ for 30 minutes in mouse G422 glioma.peak induction was found from 2 to 6 hours following hyperthermia.The significance of the program cell death induced by hyperthermia in glioma was discussed.更多还原