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立体定向32P内放疗和甲氨喋呤内化疗联合治疗脑深部神经胶质瘤

Combined CT-guided stereotactic interstitial radiotherapy of  ̄(32)P and MTX chemotherapy for treatment of deep brain gliomas

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【作者】 林岩崇陈伟建诸葛启钏郑荣远金成涛许方洪郭献忠徐云弟吴近森瞿宣兴

【Author】 Lin Yanchong;Chen Weijian;Zhuge Qichuan;et al.(Department of Neuro surgery First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000)

【机构】 温州医学院附属一院神经外科

【摘要】 报道44例脑深部神经胶质瘤采用CT导向立体定向技术,用放射性胶体磷酸铬(32P)进行瘤内放射治疗,其中30例联合甲氨蝶呤(MTX)瘤内化疗。术后经临床和CT随访6~48月,结果:临床症状和体征消失13例,改善22例,无效或恶化9例。CT证实显效4例,有效27例,微效4例,无变化4例,恶化5例。囊性较实质性效果为好,联合治疗较单纯内放疗效果好。作者认为,此法操作简单,效果确定,特别适用于深部和重要功能区的囊性神经胶质瘤,并对联合作用的机理和并发症进行了讨论。

【Abstract】 cases of deep brain gliomas treated with CT-guide stereotactic interstitial radiotherapy of  ̄(32)P, among them 30 cases combined with Methotrexate(MTX)chemotherapy with 6 ̄48 months followed-up, All clinical symptoms disappered in 13, improved in 22, no effects in 9. There were no mortality and serious complications. Authours suggest that this method is safe and precise for treatment of gliomas in the deep cerebral and brain stem,it is best for cystic gliomas.This study also demostrated the combined interstitial radiaotherapy and chemotherapy is better than interstitial radiotherapy used only.

【基金】 浙江省卫生厅科研基金
  • 【文献出处】 中华神经外科杂志 ,CHINESE JOURNAL OF NEUROSURGERY , 编辑部邮箱 ,1996年04期
  • 【分类号】R739.41
  • 【被引频次】6
  • 【下载频次】38
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