【摘要】 从牛坐骨神经提取碱性髓鞘蛋白（ＭＢＰ）免疫豚鼠建立实验性变态反应性神经炎（ＥＡＮ）的动物模型，研究脊髓Ｐ物质（ＳＰ）在ＥＡＮ发病中的作用，结果显示：预先用辣椒素耗竭豚鼠脊髓后角及初级感觉神经元中的ＳＰ，ＥＡＮ动物的细胞及体液免疫功能增强、发病加重；而在ＥＡＮ发病的高峰期，脊髓后角及背根神经节中的ＳＰ含量明显升高。提示脊髓后角及初级感觉神经元中的ＳＰ对细胞和体液免疫反应有抑制作用，参与ＥＡＮ发病过程，而发病高峰期脊髓后角及初级感觉神经元中的ＳＰ水平增高，可能反馈性地抑制自身免疫反应，使之不致于过强，起自身保护作用。更多还原

【Abstract】 TheefectsofsubstancePonthepathogenesisofexperimentalalergicneuritis(EAN)werestudiedingurineapigs.Theanimalmodelwasinducedbyimmunizationwithpurifiedmyelinbasicproteinfromthebovinesciaticnerve.Ourfindingsweredescribedasfolow:(1)Sys-temicadministrationofcapsaicintoadultguineapigscouldincreasenotonlytheincidenceandclinicalseverityofEANbutalsocelularandhumoralimmuneresponsessignificantly.(2)SubstancePcon-tentsintheL1-L5dorsalhornsofthespinalcordanddorsalrootgangliaintheEANgroupenhancedmarkedlyascomparedtothoseofthenon-EANgroup.ThesefindingsuggestedthatdepletionofSPinthespinalcordsanddorsalrootgangliainducedbycapsaicinmightpromotetheimmuneresponsesandaggravatetheseverityofEAN.WhiletheincreaseofSPcontentsatthepeakofimmuneresponsemaysuppresstheimmunesystemviaunknownfeedbackpathwaysandatenuatetheseverityofEAN.更多还原