【摘要】 为了解沥青对烧伤及其周围皮肤的影响,进行3个内容不同的豚鼠实验:实验一观察沥青对正常皮肤的影响,发现“沥青皮肤”48小时后的组织学和超微结构均发生严重病变,对照组正常。实验二观察沥青对烧伤创面的影响,发现沥青早期使烧伤创面扩大,其愈合速度、愈合创面毛囊数和真皮厚度均分别比对照组明显减慢、减少和变薄(P<0.001)。实验三观察沥青对溃疡创面的影响,发现早期沥青使溃疡创面广泛缺血坏死和炎性浸润,愈合后创面上皮组织增生明显。提示沥青对正常皮肤、烧伤和溃疡创面均有较强的腐蚀、刺激和破坏作用。因此,对沥青烧伤必须及早全面清创。更多还原

【Abstract】 This study assessed the topical effects of bitumen on burn wounds and their surrounding skin in guinea-pigs. It consisted of three different experiments. The bitumen used in this experiment was a soft tar produced by Daye Steel Plant. The first experiment showed that the skin of the bitumen group marked pathological changes under both light and electron microscopes. The second experiment suggest- ed that healing of the burn wounds of bitumen group was delayed,and less hair follicle counts and a low- er intradermal thickness were found as compared with the other groups. The third experiment indicated that the wound edges had been seriously destroyed by bitumen,leading to enlargement of the size of the ulcers,and hypertrophy of scar occurred after healing. It is concluded that bitumen,especially the soft coal tar, has more errosive,irritating and destructive effects,therefore in bitumen burns the bitumen must be immediately and entirely removed from burn wounds.更多还原