【摘要】 用兔经手术形成单侧完全性模拟唇裂,于广泛软组织潜行分离后直接缝合。术后伤口周围皮下和粘膜下定期注射具有改善伤口愈合,减少瘢痕形成的药物盐酸罂粟碱和透明质酸酶。与对照组比较和不用药组比较术后唇压低,颅颌骨全长和上颌骨全长的长度大。结果表明:瘢痕形成和局部张力过大可以明显抑制上颌骨前后径的发育。更多还原

【Abstract】 This study was designed to test the influence of pharmacological manipulation on scar con- traction and craniofacial growth in rabbits after repairing surgically created lip defects by wide undermining of soft tissue.Two pharmacological agents,i.e.papaverine hydrochloride and hyaluronidase,were inject- ed subcutaneously and submucosally in the wound.The preliminary results of this study indicated that the treatment with either papaverine or hyaluronidase for four weeks following lip repair with soft tissue under- mining significantly reduced lip pressure and decreased tension of labial wound.Analysis of the data from the lateral head cephalography revealed that the rabbits treated with such pharmacological agents exhibited significantly more anteroposterior growth than the rabbits not treated with such agents.更多还原