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胚胎中脑黑质脑内移植治疗帕金森病长期随访观察

Following-up study of transplantation of fetal substantia nigra for Parkinson’s disease

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【作者】 吴承远张庆林孙敬熙王树新徐淑军周茂德鲍秀峰黄崇熙赵经郊

【Author】 Wu Chengyuan Zhang Qinlin Sen Jingji Department of Neurosurgery,Affiliated Hospital of Shandong Medical University,Jinan 250012

【机构】 山东医科大学附属医院山东医科大学附属医院青岛市立医院解放军第88医院

【摘要】 本文报告采用胚胎中脑黑质细胞脑内移植治疗6例晚期帕金森病,包括1例脑立体定向丘脑毁损后震颤复发者,经移植治疗后获得良好放果。本组病例书氏计分平均从21分降至11分。其中2例经术后3、9、14个月 CT、MRI 随访,脑内移植物体积增大,症状和体征明显改善。

【Abstract】 Presented in this paper is treatment of 6 cases of late-stage Parkinson’s disease treated by transplantation of fetal substantial nigra.Our series included 1 patient with stereota thelamectomy.Satisfactory results were achieved in all patients.The Wehster’s scores were re- duced form 21 points to 11 points.The follow-up study 3,9,14 months after transplantation showed growth of intracranial grafts as confirmed by CT and MRI and improvement of symptoms and signs.

【关键词】 帕金森病立体定向黑质移植
【Key words】 ParkinsonismStereotacticNigra substantiaGraft
  • 【文献出处】 中华器官移植杂志 ,Chinese Journal of Organ Transplantation , 编辑部邮箱 ,1996年04期
  • 【分类号】R651.1
  • 【被引频次】7
  • 【下载频次】11
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