【摘要】 为寻求一种较理想的胰岛预处理方法,以降低其致免疫性,对新生猪胰岛进行24℃培养、准分子激光照射与冷冻保存预处理,并将预处理的胰岛移植给119只糖尿病大鼠。结果49只有效;对照组仅1只(1/9)有效。移植物存活时间:预处理组11.94±5.77天,对照组9天。结果提示新生猪胰岛经预处理后其致免疫性显著减低,异种移植效果较对照组明显提高,但移植物的平均存活时间,两组间的差异并不显著。更多还原

【Abstract】 In order to look for a better islet pretreatment technique to decrease the immuno- genicity,the studies on xenotransplantation of neonatal pig islets pretreated by 24℃ culture, Laser-irradiation and cryopreservation were conducted.Forty-nine rats (41.18%) were proved to be effective.But only 1 (11.10%) was effective in nine control rats.The survival time of the pre- treated group were 11.94±5.77days,and that of control group 9 days.The results indicated that the immunogenicity of pretreated neonatal pig islets were reduced markedly,and the effecacy of the transplantation was significantly increased compared to that of control group.更多还原