节点文献
盐酸奥昔布宁的合成
SYNTHESIS OF OXYBUTYNIN HYDROCHLORIDE
【摘要】 经酯交换法制备盐酸奥昔布宁,其中炔酯化合物以丙炔醇为原料,收率72%;α-环己基苯基羟基乙酸甲酯以扁桃酸为原料,收率25%。酯交换、成盐收率为64%。
【Abstract】 Antispasmodic and anticholinergic drug oxybutynin hydrochloride was prepared through ester exchange and salt formation in 64% yield. 4- (Dietylamino)-2-butynyl acetate was synthesized from propargyl alcohol in 72% yield,and methyl α-phenyl-α-cyclohexylglycolate was synthesized from mandelic acid in 25% yield.
【关键词】 盐酸奥昔布宁;
合成;
解痉药;
抗胆碱药;
【Key words】 oxybutynin hydrochloride; synthesis; antispasmodic; anticholinergic;
【Key words】 oxybutynin hydrochloride; synthesis; antispasmodic; anticholinergic;
- 【文献出处】 中国医药工业杂志 ,CHINESE JOURNAL OF PHARMACEUTICALS , 编辑部邮箱 ,1996年09期
- 【分类号】TQ463.2
- 【被引频次】13
- 【下载频次】227