【摘要】 β－萘甲醚在ＡｌＣｌ３存在下与丙烯腈反应，生成３－（６－甲氧基－２－萘基）丙腈；再与ＣＨ３Ｃｌ的格氏试剂反应，产物经水解得萘丁美酮。两步反应总产率约４５％。更多还原

【Abstract】 A novel route for synthesis of nabumetone under mild condition was described.2-Methoxynaphthalene reacted with acrylonitrile to form 3-(6-methoxy-2-naphthyl) propionitrile(3),then 3 was converted to nabumetone by addition of methyl magnesium chloride. The overall yield is 45%更多还原