【摘要】 合成了６个７－［４－（２，４－二氨基喹唑啉－６－基）哌嗪－１－基］－６－氟－１，８－二取代－１，４－二氢－４－氧代喹啉－３－羧酸及其类似物。对２０株细菌的体外抗菌试验结果表明，它们对革兰阴性菌无明显作用，对某些革兰阳性菌的作用较好。更多还原

【Abstract】 Some 7-[4-(2,4-diamino-6-quinazolinyl-1-piperazinyl]-6-fluoro-1,8-disubstituted-1,4-dihydro-4-oxoquinoline-3-car acids and the analogues were synthesized and they possessed good antibacterial activity against some gram-positive bacteria in vitro but had no sisrnificant effect against gram-positive bacteria.更多还原