【摘要】 观察橙皮苷对链脲佐菌素导致的糖尿病大鼠肾脏功能和形态的影响,并与氨基胍进行比较。结果表明:（1）两治疗组大鼠尿蛋白排泄量显著低于对照组P<0.05）;（2）两治疗组肾组织AGEs和LPO含量显著低于对照组（P<0.01,P<0.05）:（3）治疗组肾小球系膜增生和基底膜增厚明显减轻。提示橙皮苷在抑制蛋白非酶糖基化、预防糖尿病肾脏并发症方面具有与氨基胍相似的作用。更多还原

【Abstract】 In this study, the effect of hespridin, a natural flavonoid, on renal function and morphology in streptozotocin induced diabetic rats was evaluated. The result was compared with that of aminoguanidine which can inhibit the formation of advanced glycosylation end products (AGEs) and can decreased diabetic complications in experimental diabetes. The results showed that excretion of urinary protein, and the content of AGEs and LPO decreased, while the mesangial expansion and basement membrane thickening were retarded in diabetic rats treated with hespridin. These indicate that hespridin plays the same protective role as aminoguanidine in inhibiting formation of AGEs, thus preventing the development of nephropathy in STZ induced diabetic rats.更多还原