【摘要】 为研究硫酸镍和重铬酸钾致细胞形态学转化的联合作用，用哺乳动物细胞形态学转化试验探讨了重铬酸钾对硫酸镍致叙利亚地鼠胚胎（ＳＨＥ）细胞形态转化作用的影响。结果表明，两种受试物共同诱发ＳＨＥ细胞形态学转化的频率超过了这两种受试物分别诱发转化频率的总和，而两物先后处理条件下诱发的转化频率未见增高，提示硫酸镍与重铬酸钾共存时，可使它们的致癌危险性增大。本研究为进一步揭示镍工肺癌的病因学问题提供了新的实验依据。更多还原

【Abstract】 ThecombinedceltransformationpotencyofnickelsulfateandpotassiumdichromatewasstudiedinSyrianhamsterembryo(SHE)cels.Theresultsshowedthatthetransformationfrequencyinducedbythecoexistenceofnickelsulfateandpotasiumdichromateexcededthesumofseparatefrequenciesofthetwochemicals,whilethesuccesivetreatmentwiththetwochemicalsdidnotleadtoanincreasedtransformationfrequency,whichsuggeststhatasynergicefectbetweennickelsulfateandpotassiumdichromateappearstoenhancetheircarcinogenicrisk.Thisob-servationprovidedcomplementarylaboratorydataonetiologicalproblemsoflungcancerinnickelrefiners.更多还原