【摘要】 目的探讨气道高反应性（ＢＨＲ）的发生机制及无症状性ＢＨＲ与哮喘之间的关系。方法对１７例无症状性ＢＨＲ进行了气道粘膜的病理学研究。结果１７例中９例（５３％）气道粘膜有变应性炎症（ＡＡＩ），与哮喘缓解期患者气道粘膜的病理改变相似；８例（４７％）气道粘膜也有炎症改变，但不同于ＡＡＩ，无嗜酸粒细胞（ＥＯＳ）和肥大细胞（ＭＣ）浸润。结论无症状性ＢＨＲ者部分已有与哮喘患者类似的病理改变。更多还原

【Abstract】 ObjectiveTostudymechanismofbronchialhyperresponsiveness(BHR)andtherelation-shipbetweenasymptomaticBHRandasthma.MethodsBronchialbiopsiesweretakenthroughfiberopticbronchoscopefrom17casesofasymptomaticBHR,12casesofchronicasthmawithremisionand10normalcontrolsubjects.Bronchialmucosaswereinvestigatedbylightmicroscopyandtransmissionelec-tronmicroscope.Analysedbymorphometrictechniqueforthegranulesinbotheosinophils(EOS)andmastcels(MC).ResultsAirwayalergicinflammation(AAI)existedin9cases(53%)withasymp-tomaticBHR.Itwassimilarinbronchialmucosalpathologicchangestochronicasthmawithremision.Inflammationexistedintheother8cases(47%),butunlikeAAI,therewerenoinfiltrationofEOSandMCinbronchialmucosa.ConclusionsThepathologicalchangesofasthmainbronchialmucosawereex-istedinapartofpatientswithasymptomaticBHR.更多还原