【摘要】 为探讨甲状腺球蛋白（Tg）基因活性的改变对甲状腺疾病临床诊断的价值,对330例甲状腺病变者的 Tg 含量及其基因位点变异进行了研究。包括甲状腺癌30例(¹³¹I 治疗21例,手术治疗9例),桥本甲状腺炎89例（甲状腺功能正常59例,甲状腺功能减低30例）,甲亢211例(未治疗40例,抗甲状腺药物治疗中130例,¹³¹I 治疗后41例)。结果:330例甲状腺疾病患者 Tg 基因位点脆性表达频率皆有不同程度的改变,无着丝粒断片和微核率明显增高。经¹³¹I 治疗的21例甲状腺癌和41例甲亢病人,Fra8q22明显高于未经¹³¹I 治疗的甲状腺癌和甲亢病人（t=7.349,P<0.01）。结论:¹³¹I 辐射导致基因结构的损伤,8q22是受损伤的敏感位点。更多还原

【Abstract】 PURPOSE To study the value of thyroglobulin （Tg） gene activity changes in thyroid disease.METHODS Tg con- centration and gene activity was studied in 330 thyroid patients;including thyroid carcinoma 30 (¹³¹I therapy 21 and operation 9), Hoshimoto’s thyroditis 89 （thyroid function normal 59 and hypo 30） and hyperthyroidism 211 (untreated 40,antithyroid drug therapy 130,¹³¹I therapy 41).RESULTS There were changes with various degree about fragile sites express frequence and signifi- cant elevation in acentric chromosome fragment,and micronucleus in 330 thyroid disease.In 21 thyroid carcinoma and 41 hyper- thyroidism treated by ¹³¹I,Fra 8q22 markly increased than that of untreated groups （t=7.349,P<0.01）.CONCLUSIONS ¹³¹I irradiation leads to destruction of Tg gene structure and the 8q22 was the most sensitive one.更多还原