【摘要】 采用放射配基结合分析法,在测定胞浆雌激素受体(EcR)的同时分析胞核雌激素受体(EnR)含量,以评估其对乳腺癌、卵巢癌组织 ER 状态的影响。在151例乳腺癌组织中,EcR、EnR 同时阳性的检出率为36.42%,叫显低于 EcR 的阳性率(55.63%);124例卵巢癌组织中,EcR、EnR 同时阳性的检出率为34.68%,亦明显低于 EcR 的阳性率(51.61%)。在 EcR 阳性组织中有65.48%的乳腺癌和67.19%的卵巢癌可以同时在胞浆胞核中测到较高水平的 ER,提示在判断 ER状态时,综合评价 EcR、EnR 较单纯分析 EcR 含量更为准确。更多还原

【Abstract】 PURPOSE To assess the significance of estrogen receptor in cell nucleus in the assessment of the ER status of pa- tients with breast cancer and ovarian cancer.METHODS 151 breast cancer tissues and 124 ovarian cancer tissues were analyzed for their EcR and EnR using radioligand binding assay (RBA).RESULTS In 36.42% of the breast cancer tissues,both EcR and EnR were positive.This rate was significantly lower than that of tissues with positive EcR alone (55.63%).In the ovarian cancer tissues,the rate of both EcR and EnR position (34.68%) was also significantly lower than that of EcR positive alone (51.61%).Only 65.48% of EcR-positive breast cancer tissues and 67.19% EcR-positive ovarian cancer tissues were accompa- nied by EnR positive.CONCLUSIONS To assess the ER status of breast cancer or ovarian cancer,it is importance to analyse not only EcR but also EnR.更多还原