【摘要】 目的探讨高剂量率腔内后装治疗在鼻咽癌放疗中的作用。材料与方法从１９９２年１月至１９９３年６月，１１０例Ⅰ、Ⅱ期鼻咽癌患者随机分为外照射加高剂量率腔内后装治疗组（综合放疗组）和单纯外照射组（对照组）。综合放疗组外照射鼻咽剂量５６～６０Ｇｙ／２８～３０次／５、６～６周，腔内治疗鼻咽顶壁粘膜下０．３ｃｍ给量８Ｇｙ３次／１．５～２周。对照组外照射鼻咽剂量６６～７２Ｇｙ／３３～３６次／６．６～７．２周。结果治疗后３６个月局部控制率综合放疗组优于对照组（９８，２％对８５．５％，Ｐ＜０．０５）；张口困难发生率，综合放疗组低于对照组（７．３％对４７．３％，Ｐ＜０．００５）。结论外照射加高剂量率腔内后装治疗可提高早期（Ⅰ、Ⅱ期）鼻咽癌的局部控制率。更多还原

【Abstract】 Purpase To evaluate the effect of nasopharyngeal carcinoma(NPC)treated by intracavitary brachytherapy of the high dose rate. Materials and Methods From January 1992 to June 1993,110 stageⅠand Ⅱ NPC patients were prospectively randomized in to combined external radiation and intracavitary brachytherapy(combination radiotherapy group)and external beam therapy alone(control group).In combination radiotherapy group.patients received extemal beam for 56～60y/28～30f/5.6～6w,followed by brachytherapy boost of 24Gy/3f/1.5～2w at the reference point(0.3 below mucosa at the nasopharyngeal roof).For control group,patients received external beam ouly with the total dose of 66～72Gy/33～36f/6.6～7.2w.Results All patients were followed up for more than 3 years. Patients received combination radiotherapy group had a better local control than those of control group(98.2 % versus 85.5%,P<0.05)within 3 years,and they had lower tismus than those of control group(7.3 % versus 47.3%,P<0.005).Conclusion External radiation plus intracavitary brachytherapy can improve local control rate for nasopharyngeal carcinoma.更多还原