【摘要】 目的 :回顾性分析非小细胞肺癌术后残留或 (和 ) N1～ 2 放疗的疗效。材料与方法 :对 1985～1993年间 2 72例 NSCLC术后残留或 (和 ) N1～ 2 患者采用 Kaplan- Meier生存曲线 ,L og- rank检验和COX多因素回归分析法探讨影响术后放疗疗效的预后因素。结果 :生存率随 N0 、N1、N2～ 3 依次明显递减(P<0 .0 5 )。姑息切除含大血管或 (和 )心包侵犯及未切者的生存率和局控率明显低于单纯切端阳性或(和 ) N1～ 2 者 (P<0 .0 1)。照射剂量 <4 0 Gy者的生存率和局控率明显低于 >4 0 Gy各组 (P<0 .0 1)。鳞癌的生存率和局控率明显高于腺癌和未分化癌 (P<0 .0 1)。结论 :病理类型、术后残留部位与切除与否以及照射剂量是影响生存率的主要因素。性别、年龄和术后放疗开始时间对预后无明显影响更多还原

【Abstract】 Purpose the prognostic factors of postoperative radiotherapy for non-small cell lung cancer (NSCLC) were retrospectively reviewed. Materials and Methods: 272 patients with the residues and/or positive lymph nodes of NSCLC were treated by radiotherapyfrom 1985 through 1993. Kaplan-meier survival curve and Cox regression model were used to evaluate the prognostic factors.Results: The survival rates were gradually decreased from N 0,N 1,N 2 and N 3 (P<0.05). The survival rates and local control rates in the palliative resection or non-resectable patients (invasion of the great vessel or pericardium) were markedly decreased compared with those of stump residues after operation and/or N 1～2 (P<0.05).Patients received radiation dose of <40Gy gave a poorer survival than those of >40Gy. Patients with squamous carcinoma gave a better local control rate than those of adenocarcinoma and anaplastic carcinoma. Conclusion: Stage, pathologic type, radiation dose and pattern of invasion are the main prognostic factors. The sex, age and interval between operation and radiotherapy had no significant effect of the prognosis.更多还原