【摘要】 目的：探讨癌基因ｃ－ｅｒｂＢ２在人宫颈鳞状上皮细胞癌（鳞癌）中的表达及其与生物学行为及预后的关系。方法：采用免疫组织化学方法，检测宫颈鳞癌６２例、宫颈上皮内瘤变（ＣＩＮ）９例及正常宫颈（１０例）的宫颈上皮组织中ｃ－ｅｒｂＢ２的表达。结果：６２例鳞癌中，１９例细胞呈阳性染色，９例ＣＩＮ中１例呈阳性染色，正常宫颈上皮无一例呈阳性染色。细胞学１、２和３级阳性率分别为１２．５％、２７．６％和５２．９％，１级及２级与３级比较，差异有显著意义（Ｐ＝０．０１９）。手术治疗的２０例患者中，６例阳性染色者，３例有盆腔淋巴结转移，１４例例阴性染色者，仅１例淋巴结转移，两者比较，差异有显著意义（Ｐ＝０．０３２）。ｃ－ｅｒｂＢ２阳性表达者，５年生存率（３１．５％）明显低于阴性者（７４．４％，Ｐ＜０．００１）。结论：癌基因ｃ－ｅｒｂＢ２表达与宫颈鳞癌生物学行为及预后相关，检测其表达可能作为宫颈鳞癌预后判断的参考指标更多还原

【Abstract】 Objective:Toinvestigatetherelationshipbetweenc-erbB2oncoproteinexpressionandbiologicbehaviorandprognosisofcervicalsquamouscelcancer.Method:Immunohis-tochemistrywasusedtoexaminethec-erbB2oncoproteinexpressionin62casesofcervicalsequa-mouscelcancer,9casesofcervicaliutraepithelicalneoplasia(CIN)and10casesofnormalepidermaltissuessectionofthecervix.Results:Nineteenof62cancersand1of9casesofCINshowedpositivestaining.Noneofnormalepitheliumshowedpositive.Incervicalcancerthepositivestainingrateofc-erbB2oncoproteiningrade1,2and3was12.5%,27.6%and52.9%respectively.Therewasasignificantdifferencebetweengrade1+2andgrade3(P=0.019).In20casesoperatedon,3of6caseswithpositivestaininghadpelviclymphnodemetastasis,whileonly1of14caseswithnegativestaininghadmetastasis(P=0.032).The5-yearsurvivalrateofpositivestaininggroupwassignifi-cantlylowerthanthatofnegativegroup(31.5%Vs74.4%,P<0.001).Conclusion:Thec-erbB2oncoproteinexpressiononcervicalsequamouscelcancerwasrelatedtoagressivebiologicbehaviorandpoorprognosis.更多还原