【摘要】 目的：测定妇女腹腔液内皮素－１（ＥＴ－１）和心钠素（ＡＮＰ）浓度，探讨其在结扎术后盆腔静脉瘀血综合征（ＰＶＣＳＳ）发病中的作用。方法：应用放射免疫技术对２１例ＰＶＣＳＳ患者（ＰＶＣＳＳ组）腹腔液及血浆中ＥＴ－１和ＡＮＰ浓度、腹腔液量和巨噬细胞密度进行测定，并与１２例绝育术后正常妇女（ＮＷＳ组）、１１例正常妇女（ＮＷ组）进行比较。结果：ＰＶＣＳＳ组腹腔液ＥＴ－１浓度、ＥＴ－１／ＡＮＰ比值、巨噬细胞密度均低于ＮＷＳ组和ＮＷ组（Ｐ＜０．００５，Ｐ＜０．００１，Ｐ＜０．００１），且均与疾病严重性评分呈负相关（Ｐ＜０．０５），但腹腔液量多于ＮＷＳ组和ＮＷ组（Ｐ＜０．００１）；各组巨噬细胞密度均与ＥＴ－１浓度呈正相关（Ｐ＜０．０５）；各组血浆ＥＴ－１和ＡＮＰ浓度间差异无显著性（Ｐ＞０．０５）。结论：妇女腹腔液含有一定浓度ＥＴ－１，腹腔液ＥＴ－１浓度和ＥＴ－１／ＡＮＰ比值降低，与ＰＶＣＳＳ发病有关。更多还原

【Abstract】 Objective:Todemonstratethepresencesofendothelin-1(ET-1),atrialnatriureticpeptide(ANP)inperitonealfluidofwomenandtheirefectsonpathogenesisofpelvicvenousconges-tionsyndromeaftersterilization(PVCSS).Methods:Thisrandomizedcontroledstudydeterminedthecon-centrationsofET-1andANPinbothperitonealfluidandplasma,countsofmacrophageinperitonealfluidandvolumesofperitonealfluidin21casesofPVCSS,12normalwomenaftersteril-izationand11normalwomenascontrolinearlyfolicularphasebyradioimmunoassay.Results:con-centrationsofET-1,ratioofET-1/ANPandcountsofmacrophageinperitonealfluidwithPVCSSwerelowerthanthoseincontrol(P<0.005,P<0.001,P<0.001)andalhadsignificantnegativecorelationwithscoresquantifyingtheseverityofPVCSS(P<0.05),butvolumesofperitonealfluidinPVCSSwerelargerthanthatincontrol(P<0.001);countsofmacrophageinperitonealfluidhadsignificantpositivecorelationwiththeconcentrationsofET-1ofperitonealfluidinalthethreegroups(P<0.05);plasmaconcentrationsofET-1andANPdidn′tshowanysignificantdiferencesamongthethregroups(P>0.05).Conclusions:ET-1waspresentinperitonealfluidofnormalwomen.LowerconcentrationsofET-1and(or)lowerratioofET-1/ANPinperitonealfluidcon-tributedtothepathogenesisofPVCSS.更多还原