【摘要】 目的：探讨血浆纤维结合蛋白（Ｆｎ）、纤溶酶原活性抑制因子（ＰＡＩ）及抗凝血酶－Ⅲ（ＡＴ－Ⅲ）在妊高征发病中的作用。方法：将９４例孕妇分为三组：（１）安慰剂组，４６例，服用安慰剂；（２）治疗组，４８例，服用小剂量阿司匹林；（３）妊高征组，２０例，为在上两组中发生妊高征的患者。采用免疫凝胶火箭电泳等方法分别检测三组孕妇血浆Ｆｎ、ＰＡＩ及ＡＴ－Ⅲ的含量。结果：妊高征组Ｆｎ及ＰＡＩ水平显著高于治疗组及安慰剂组。两组比较，差异具有显著性（Ｐ＜０．０１）；而妊高征组ＡＴ－Ⅲ却显著低于治疗组及安慰剂组。结论：Ｆｎ、ＡＰＩ及ＡＴ－Ⅲ的平衡失调在妊高征发病中有重要意义。更多还原

【Abstract】 Objective:Toinvestigatesomeposiblecausesofpregnancyinducedhypertension(PIH).Methods:Plasmaantithrombin(AT-Ⅲ),fibronectin(Fn),plasminogenactivatorinhibitor(PAI)levelsweredeterminedat26～28,37～38gestationalweeksand24～72hoursafterdeliveryin114pregnantwomenwhosemeanarterialpresure(MAP)≥12kPaorbodyweightindex≥0.24.WomenwerelongitudinalyfolowedtoobservewhetherPIHdevelopedanditsrelationtothechangesoftheaboveparameters.Results:AT-ⅢleveldecreasedandFn,PAIlevelsincreasedsig-nificantlyinPIHpatients(P<0.01).Conclusions:Theendothelialcelsdamageresultsinanin-creaseofthromboxaneA2(TXA2),decreaseofprostaglandinI2(PGI2),andincreaseofPAI,Fn,de-creaseofAT-Ⅲ,aswelastheincreaseofangiotensinⅡsensitivity.Althesechangesleadtovas-cularconstriction.Astheresults,renalanduterineplacentabloodflowdecrease,thenPIHoccurs.更多还原