【摘要】 为探讨正常新生儿早期和窒息后患儿血浆中内皮素（ＥＴ）和一氧化氮（ＮＯ，以ＮＯ－２／ＮＯ－３值代表）的变化，采用放射免疫法和镉柱比色法测定４２例窒息新生儿和１８例正常新生儿血浆ＥＴ、ＮＯ水平变化。结果表明，窒息急性期ＥＴ增高，ＮＯ－２／ＮＯ－３值降低，尤以重度窒息儿显著；恢复期ＥＴ降低，ＮＯ－２／ＮＯ－３值在足月儿窒息组表现为持续增加，早产窒息儿则降低；ＮＯ－２／ＮＯ－３值与各围产因素无显著相关。提示ＥＴ和ＮＯ水平与窒息严重程度呈正相关。更多还原

【Abstract】 Dynamicvariationsofplasmaendothelin(ET)andnitriteandnitrate(NO-2/NO-3)levelsweremeasuredin42asphyxiatednewborninfantsand18normalinfantsbyradioimmunoassayandcadmium-columnreductionspectrophotometry.PlasmaETlevelmarkedlyelevatedandplasmaNO-2/NO-3levelfelsignificantlyinacutestageofasphyxia,especialyofsevereasphyxia.TherewasagradualdecreaseinplasmaETlevelinitsconvalescentstage.However,plasmaNO-2/NO-3levelwaselevatedpersistentlyinful-terminfantsbutremainedlowinpreterminfants.Theseresultssug-gestedthattherewasagoodpositivecorrelationbetweentheseverityofilnessandtheabnormalex-cretionofETandnitricoxide(NO).TheaugmentationofNOproductioninconvalescentstagemaybeassociatedwiththemechanismofbraininjuryandepilepsyinful-termasphyxiatedinfants.更多还原