【摘要】 为提高对各种前列腺增生性病变与癌的认识和鉴别诊断水平，用抗高分子量的细胞角蛋白单克隆抗体３４ＢＥ１２做免疫组织化学染色特异地显示前列腺的基底细胞，并对前列腺腺癌及前列腺增生性病变进行了鉴别，其中前列腺腺癌２１例、前列腺上皮内肿瘤３０例、前列腺非典型性腺瘤样增生５例、前列腺基底细胞增生８例、前列腺萎缩１１例、萎缩后增生４例、前列腺筛状增生３例。结果显示前列腺腺癌基底细胞均丢失，而前列腺增生性病变基底细胞绝大多数保存完好，只少数３级前列腺上皮内肿瘤和非典型性腺瘤样增生基底细胞不完整。研究表明特异地显示基底细胞的高分子量细胞角蛋白３４ＢＥ１２在前列腺腺癌鉴别诊断中有应用价值。更多还原

【Abstract】 Inordertounderstandthecharacteristicsofproliferativeandmalignantprostatelesionsandtoimprovethediferentialdiagnosis,immunohistochemicalmethodsusinghighmolecularweightcy-tokeratinmonoclonalantibody34BE12tostainthebasalcelsandtodiferentiateprostatecancerfromhyperplasiain82prostatebiopsiesandspecimens,whichincluded21adenocarcinoma,30intraepitheli-alneoplasia,5atypicaladenomatoushyperplasia,8basalcelhyperplasia,11atrophyofprostate,4post-at-rophichyperplasiaand3cribriformhyperplasia.Itwasdemonstratedthatthebasalcellayerwaslostinalprostateadenocarcinomas,butexistedinmostoftheproliferativelesionsexceptforatypicaladeno-matoushyperplasiaandgrade3intra-epithelialneoplasiainwhichthebasallayerwasdisruptedinsome-cases.Thestudyshowedthatthe34BE12antibodywasusefulinthediferentialdiagnosisofprostateadenocarcinoma.更多还原