【摘要】 采用静注５－ＨＴ、Ｐｂ－Ａｃｅｔ同时口灌ＬＰＳ对大鼠进行肠源性内毒素血症造模。造模后三小时，测血、组织ＰＬＡ２和ＳＯＤ活性。结果表明，模型组大鼠血清、肺、肝、肾组织匀浆的ＦＬＡ２活性明显高于正常组，而大承气汤治疗组则与正常组无异；相反模型组肺、肝、肾组织匀浆ＳＵＤ活性，则较正常组明显下降，而大承气汤治疗组则与正常组无异，说明大承气汤在肠源性内毒素血症病理形成过程中能明显抑制ＰＬＡ２活性的升高，有益于减轻组织的损害；此外，又可阻止ＳＯＤ活力的下降，从而增强对过量产生的Ｏ２的消除能力。更多还原

【Abstract】 heanimalmodelofenterotoxemiawasinducedbygivingLPSorallyandintravenuuslyinjectedwifh5-HTandleadacetatesimultaneouslytorats.Theanimalsweredividedintothreegroups:normalgroup,modelgroupandDTtreatinggroup.3hoursafterthemodelwasmadePLA2activityinserumandPLA2andSODactivityintissuehomogenatesweredetect-ed.TheresultsshowedthatPLA2activityinserumandinlung,liverandkidneyhomo-genatesofmodelratsweremuchhigherthannormalgrouprats.TheresultofDTtreatinggroup,however,showednodifferencewithnormalgroup.Onthecontrary,SODactivityintissuehomo-genatesofmodelratsshowedsignificantdecreasecomparedwithnormalrats.Butltdidn-tshowanydifferenceinDTtreainggroupwithnormalgroup.ltsuggestedthatDTcouldinhibittherisingofPLA2activityandthedecreasingofSODactivityintheformingofenterotoxemia,whichisbeneficialforalleviatingtissueinjury.Thelatterchangescouldre-inforcetheclearingabilityofextra-generatedO2.更多还原