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糖尿病患者血清BGP与骨密度变化的研究

Study on changes of Serum bone Gla-protein and bon mineral density in diabetics

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【作者】 潘时中严孙杰张松菁汤冰王敏

【Author】 Pan Shizhong; Yan Sunjie; Zhang Songqin; Tang Bin and Wang Min (Department of Endocrinology, The First Affiliated Hospital of Fujian Medical College, Fuzhou 350004, China)

【机构】 福建医学院附属第一医院内分泌科

【摘要】 本文应用放射免疫分析方法对60例正常人及74例糖尿病患者的血清BGP进行了测定,并就其与BMD、血Ca、P及AKP等进行比较分析。结果表明:糖尿病患者血清BGP明显降低,而血Ca、P及AKP仍在正常范围,血清BGP与BMD呈负相关。说明血清BGP测定与BMD一样可以作为骨质疏松、糖尿病等代谢性骨病诊断与研究的一种敏感指标。

【Abstract】 A determination was made of serum BGP in 60 normal subjects and 75 cases of diabetes with radioimmunoassay, and a comparative analysis was made of BMD, serum Ca, P, AKP. The results showed that serum BGP in diabetics dropped significantly (0. 0l<P<0.05), but serum Ca, P, AKP remained normal. Serum BGP and BMD showed negative correlation (r=-0.326, P<0.05). This indicates that determination of serum BGP, like BMD, can be used as a sensitive index for the diagnosis and study of such metabolic bone diseases as osteoporosis and diabetes.

  • 【文献出处】 中国骨质疏松杂志 ,CHINESE JOURNAL OF OSTEOPOROSIS , 编辑部邮箱 ,1996年03期
  • 【分类号】R587.1
  • 【被引频次】7
  • 【下载频次】22
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