【摘要】 应用三苯氧胺（ＴＡＭ）抑制实验对３９例乳腺癌ＥＲ（＋）病人进行了检测。其中２４例ＴＡＭ抑制实验有不同程度的抑制阻断，抑制率从１０％～１００％。其余１５例ＥＲ（＋）者，而ＴＡＭ抑制率为零。不同组织学类型ＴＡＭ抑制率实验似有差异，髓样癌的阳性检出率较浸润性导管癌高。从理论上讲，ＴＡＭ在部分ＥＲ（＋）病人体内，并不能阻断Ｅ２与受体结合，因而对ＴＡＭ抑制实验阴性的病人，ＴＡＭ不能起到治疗效果。因此建议进行激素受体测定时，加测ＴＡＭ抑制实验，以指导临床用药。更多还原

【Abstract】 TAM inhibition test was performed in 39 cases of breast cancer with ER(+).The results showed that TAM was found positive in 24 cases(61%)and negative in 15(39%)respectively.The TAM positive rate in medullary cancer was higher than that in other pathologic types of breast tumors and it was the lowest in ductal cancers.It was shown that TAM was unable to inhibit E2 to combine with its receptor in some patients.It suggested that in patients with TAM negative inhibition test,TAM perhaps have no therapeutic effect.So combining ER and TAM inhibition test in breast cancer patients might improve the TAM therapeutic result.更多还原