【摘要】 65例晚期胃癌患者随机应用榄香烯乳氟脲嘧啶(EF方案,31例)与丝裂霉素氟脲嘧啶(MF方案,34例)进行同期治疗,有效率分别为32.3%(10/31),41.2%(14/34),两组间无显著差异(X~2＝0.55,P＞0.10)。EF方案毒副反应有恶心,呕吐100%(31/31),静脉炎及白细胞下降均为58.1%(18/31),发热19.4%(6/31),血小板减少仅3.2%(1/31)。研究表明,EF方案对晚期胃癌有较好疗效而血液学毒性较低,更适合于年老体弱及骨髓功能不良者的治疗。更多还原

【Abstract】 A randomized trial on sixty-five patients with gastric cancer (12 cases of stage Ⅲ ,53 cases of stage Ⅳ ) was performed using EF regimen (elemene plus fluorouracil) and MF regimen (mitomycin-C plus fluorouracil). The immediate response rate achieved in the former was 32. 3% (10/31) as compared with 41. 2% (14/34) of the latter. The difference between these two protocols was not significant (X2 = 0. 55,P>0. 10).The side effects of EF regimen consisted of nausea and vomiting in all the patients and phlebitis in 58. 1% (18/31 ). 19. 1% of the patients had fever. The incidence of thrombocytopenia was found in 3. 2% (1/31). It is concluded that EF regi-rnen had a remarkable effect and lower hematologic toxicity for patients with advanced stomach cancer. Therefore,it is justified in elder patients with marrow depression.更多还原