节点文献
古方地黄饮子抗衰老作用的研究
StudyonAnti-ageingEfectsofAncientRecipe
【摘要】 实验观察了古方地黄饮子的抗衰老作用。结果表明地黄饮子（２％和４％）能延长果蝇平均寿命（Ｐ＜０．０５）和最高寿命；能降低３月龄小鼠血浆过氧化脂质（ＬＰＯ），升高红细胞谷胱甘肽（ＧＳＨ）（２０ｇ·ｋｇ－１·ｄ－１·２８ｄ，ｉｇ，Ｐ＜０．０５或Ｐ＜０．０１）；能显著减低９月龄小鼠随增龄增加的血浆ＬＰＯ（１．０ｇ＆２．５ｇ·ｋｇ－１·ｄ＼｛－１＼｝·１６ｗ，ｉｇ，Ｐ＜０．０５）；能抑制体外大鼠肝、脑匀浆ＬＰＯ生成（Ｐ＜０．０１），抑制率与剂量呈良好相关；延长小鼠游泳和常压下耐缺氧时间（２０ｇ＆１２ｇ·ｋｇ－１·ｄ＼＋－１·８ｄ，ｉｇ，Ｐ＜０．０５）。结果提示地黄饮子有延寿抗衰作用。
【Abstract】 Anti-ageingefectsofDihuangYinzi(DHYZ),afamousrecipeoftonifyingthekidneyintraditionalChinesemedicine,wereinvestigatedinanimalexperiments.TheresultsindicatedthatDHYZ(culturemediumcontaining2%&4%DHYZ)couldprolongthemeanandmaximunlifespaninDrosopholamelanogasterofAmericanwildtype.DHYZ(ig,10g&20g·kg-1·d-1for1or16weeks)couldsignificantlydecreaseplasmaLPOandenhanceerythrocyteGSHinthemiceaged3and9months).LPOinducedbythehemogenatedofthebrainandliverofratinvitrobeinggiven25μl,50μland100μlofDHYZweremarkedlyde-creased.Therewasapositivecorelationbetweenconcentrationofthedrugandtheinhibitionrate.DHYZ(ig20g·kg-1or12g·kg-1·d-1for8days)couldobviouslyelongatesurvivaltimeunderhypoxiaandthedurationofswimminginthemice.ItissuggestedthatDihuangYinzimayhaveanactionofprolongingthelifespananddelyaingageing.
【Key words】 raditionalChineseMedicine； DihuangYinzi； Anti-ageing； Lifespan； LPO； ErythrocyteGSH；
- 【文献出处】 中国药科大学学报 ,JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY , 编辑部邮箱 ,1996年05期
- 【分类号】R285
- 【被引频次】31
- 【下载频次】296