【摘要】 研制了对乙酰氨基酚溶液剂（５ｇ／０．１Ｌ），建立了高效液相色谱法（ＨＰＬＣ－ＵＶ）测定血药浓度。以Ｔｙｈｅｎｏｌ○Ｒ（ＭｃＮｅｉｌ，ＵＳＡ）混悬液为对照品，研究了自制对乙酰氨基酚溶液剂在８名健康志愿受试者体内的药物动力学。结果显示，对乙酰氨基酚溶液剂在人体内的动力学以二室线性模型描述为宜，其主要药物动力学参数分别为α＝０．６１５２ｈ－１，β＝０．１９２５ｈ－１，ｔ１２＝３．６２ｈ，Ｋａ＝３．８８６４ｈ－１，ＡＵＣ０→∞＝７７．２３ｈ·μｇ／ｍｌ，相对于Ｔｙｌｅｎｏｌ○Ｒ混悬剂的生物利用度为９８．８５％。更多还原

【Abstract】 Paracetamol liquid (5 g/0.1 L) was developed in the convenient, fast and effective relief of children′s fever and pain. A simple and sensitive high performance liquid chromatographic method (HPLC UV) was establisbed with detection limit of 0.016 μg/ml, and can be used for the analysis of biological samples of paracetamol. Pharmacokinetics of paracetamol(self made) was evaluated in 8 healthy volunteers to assess the disposition in vivo of paracetamol. It was suggested that kinetics of paractetamol in vivo fitted two compartmental model, and that main pharmacokinetics parameters of paracetamol liquid were α =0.6152 h -1 , β =0.1925 h -1 , t 12 =3.62 h, K a=3.8864 h -1 and AUC 0→∞ =77.32 h·μg/ml. The relative bioavailability of paracetamol liquid was 98.85%, compared with the control of Tylenol ○R suspension.更多还原