【摘要】 观察了７例（２例非何杰金ｉ淋巴瘤Ⅲ期、３例急淋、１例急粒及１例神经母细胞瘤Ⅳ期）儿童恶性肿瘤病人接受强烈化疗联用ｒｈＧ－ＣＳＦ后，外周血干细胞（Ｐｅｒｉｐｈｅｒａｌｂｌｏｏｄｓｔｅｍｃｅｌｌ，ＰＢＳＣ）动员上升情况。ＰＢＳＣ上升的最明显特点是与外周血白细胞总数上升的幡度平行；ＷＢＣ的上升幅度与患儿骨髓是否受肿瘤细胞侵犯有关。本文显示ＣＤ３４＋细胞与粒单细胞集落形成单位（ＧＭ－ＣＦＵ）有较好的相关关系（ｒ＝０．８７，Ｐ＜０．００１），提示ＣＤ３４＋细胞可以预测ＰＢＳＣ开始单采的时机。更多还原

【Abstract】 Abstract: Mobilization of peripheral blood stem cells (PBSC)after intensive chemotherapy followed by rhG-CSF was studied in seven cases of maligant tumor in children. There were 2cases of non-Hodgkin,s lymphoma (stage 111), 3 cases of acute lymphoblastic leukemia, 1case of acute myeloblastic leukemia, 1 case of neuroblastoma with invovement of bone marror. PBSC was well correlated with the exponential of white blood cells, and the exponentialof WBC was slow in patients with involvement of bone marrow than those without. This result also showed that the rate of CD34 positive cells in peripheral blood was correded to thatof GM-CFU (r= 0. 87,P<0. 001),which indicated that the CD34 positive cells in blood couldbe used to predicting the time for PBSC harvesting.更多还原