【摘要】 血卟啉为存在于肿瘤组织中的自体荧光物质,它在诱导组织自体荧光法诊断肿瘤中起着较为重要的作用。本研究通过对36例大肠癌患者的癌组织、癌旁与远癌组织中血卟啉含量采用化学抽提与荧光分析法进行定量分析,结果显示:血卟啉含量(ng/g组织)大肠癌组织(39.01±14.49)>癌旁组织(29.16±9.78)>远癌组织(23.16±9.04);而对于癌组织之间比较:大肠癌各病理类型之间血卟啉含量无明显差异,直肠癌与结肠癌组织之间也无显著差异。因此我们认为大肠癌组织能特异积聚内源性血卟啉,为自体荧光诊断大肠癌提供理论依据。更多还原

【Abstract】 Hematoporphyrin (HP) is a kind of auto- fluorescence substance in tumour tissue, it plays important role in diagnosis tumour with in-ducing tissue auto - fluorescence. Our research analyse quantitatively the content of HP in the tissues of 36 patients of large bowel carcinoma by chemical extraction and fluorescence analysis. The result shows that the content of HP (ng/g tissue) is carcinoma tissue (39.01 ±14. 49)>paracarcinoma tissue(29.16 ±9.78) >distal carcinoma tissue (23.16±9.04)(P<0.05), between large bowel carcinoma pathologi-cal type, and between rectal carcinoma and colon carcinoma the content of HP is no significance, So we think large bowel carcinoma can ac-cumulate endogenous HP, and providing with basis theory on dingnosis large bowel carcinoma by ways of auto- fluorescence.更多还原