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M1,M2受体激动剂和阻滞剂对犬呼吸的影响
Effects of M 1 and M 2 receptor agonists and blockers on dog respiration 1
【摘要】 目的:研究M1和M2受体激动剂和阻滞剂对犬呼吸的影响.方法:用RM86多导生理记录仪通过胸带式呼吸换能器测定RR,TV和MVV,并取动脉血测pO2,pCO2和pH.结果:发现M1R激动剂Pil和M2R激动剂6βANiv或椎动脉给药分别产生呼吸兴奋和抑制,RR,MVV增高或降低(P<005),血气亦出现相应变化.M1R阻滞剂Pir,Sco和M2R阻滞剂AFDX116,Atr分别拮抗甚至翻转Pil的呼吸兴奋和6βAN的呼吸抑制作用.结论:激动呼吸中枢M1R呼吸兴奋,激动呼吸中枢M2R呼吸抑制,阻断之则作用相反.
【Abstract】 IM: To study the effects of M 1 and M 2 receptor agonists and blockers on dog respiration. METHODS: Using thoracic respiratory transducer and RM 86 multipurpose polygraph to determine respiratory rate (RR), tidal volume (TV), and minute ventilation volume (MVV), and DH 100G blood gas analysis instrument to analyze p O 2, p CO 2 and pH. RESULTS: Pilocarpine (Pil, an M 1 R subtype agonist) 0 5, 1, and 2 mg·kg -1 iv caused increases in RR, MVV, and p O 2, and a decrease in p CO 2. The excitatory effects of Pil were antagonized by pretreatment with pirenzepine (Pir, 3 mg·kg -1 , iv) and scopol ̄amine (Sco, 2 mg·kg -1 , iv). The iv injections of a novel M 2 R subtype agonist, 6β acetoxy nortropane (6β AN) 2, 5, and 20 μg·kg -1 caused decreases in RR, MVV, and p O 2 and an increase of p CO 2. The actions of 6β AN were antagonized by iv pretreatment with AF DX116 {11 2[[2 [(diethylamino)methyl] 1 piperidinyl]acetyl] 5,11 dihydro 6Hbenzodiazepine 6 one, 0 5 mg·kg -1 } and atropine (Atr, 2 mg·kg -1 ). Similar results were obtained when smaller doses of Pil (0 2, 0 4, and 0 8 mg·kg -1 ) and 6β AN (0 25, 0 5, and 1 μg·kg -1 ) were injected into the vertebral artery. Pir and Sco also antagonized the excitatory effects of Pil, and AF DX116 and Atr antagonized the inhibitory effects of 6β AN on respiration. CONCLUSION: Stimulating M 1 R of the respiratory center caused excitation of the respiration while stimulating the M 2 R subtype caused inhibition of the respiration.
【Key words】 muscarinic receptors; pilocarpine; nortropanes; scopolamine; pirenzepine; atropine; respiration;
- 【文献出处】 Acta Pharmacologica Sinica ,中国药理学报(英文版) , 编辑部邮箱 ,1996年03期
- 【分类号】R-332
- 【下载频次】4