【摘要】 目的：探讨白三烯特异性拮抗剂４氧８［对（４苯丁氧基）苯甲酰氨基］２（５四唑基）４Ｈ１苯并吡喃半水合物（ＯＮＯ１０７８）对气道辣椒素敏感的感觉神经功能的调节作用．方法：观察豚鼠肺内压（ＩＰＰ）、伊文思蓝渗出量和离体支气管平滑肌收缩反应．结果：辣椒素（Ｃａｐ，００５ｍｇ·ｋｇ－１，ｉｖ）、Ｐ物质（ＳＰ，１μｇ·ｋｇ－１，ｉｖ）和白三烯Ｃ４（ＬＴＣ４，０５μｇ·ｋｇ－１，ｉｖ）增高ＩＰＰ和支气管及肺内气道伊文思蓝渗出量，ＯＮＯ１０７８（００３ｍｇ·ｋｇ－１，ｉｖ）完全阻断ＬＴＣ４的作用，减弱Ｃａｐ的作用，但不影响ＳＰ的作用．ＯＮＯ１０７８（１μｍｏｌ·Ｌ－１）还显著抑制Ｃａｐ收缩支气管平滑肌，对ＳＰ无效．结论：ＯＮＯ１０７８通过抑制感觉神经肽释放而部分抑制Ｃａｐ的作用．更多还原

【Abstract】 AIM: To study the effect of 4 oxo 8 [ p (4 phenylbutyloxy)benzoylamino] 2 (tetrazol 5 yl) 4H 1 benzopyran hemihydrate (ONO 1078), a specific leukotriene antagonist, on capsaicin (Cap) sensitive sensory nerve functions in the airways, and clarify the modulating roles of endogenous peptido leukotrienes. METHODS: Changes in intrapulmonary pressure (IPP), Evans blue extravasation in airways, and contraction of bronchial smooth muscles of guinea pigs induced by Cap, substance P (SP) and leukotriene C 4 (LTC 4) were observed. RESULTS: Cap (0 05 mg·kg -1 , iv), SP (1 μg·kg -1 , iv) and LTC 4 (0 5 μg·kg -1 , iv) enhanced IPP, and Evans blue extravasation in bronchi and intrapulmonary airways. ONO 1078 0 03 mg·kg -1 , iv comple￣tely blocked the responses to LTC 4, attenuated those to Cap, but had no effect to SP. In isolated bronchial smooth muscles, ONO 1078 (1 μmol ·L -1 ) inhibited the contractile response to Cap, but not to SP. CONCLUSION: ONO 1078 partly inhibits Cap sensitive sensory nerve actions in airways, but has no direct effect on SP, a sensory neuropeptide.更多还原