【摘要】 目的:研究索布佐生（Sob）与阿霉素（Dox）联合应用的抑瘤作用以及Sob对Dox诱导的心脏毒性的影响。方法:DBA/2小鼠接种P388细胞,次日起iv Dox 2mg·kg^-1·d^-1×3d及4mg·kg^-1·d^-1×1 d,ig Sob 20mg·kg^-1·d^-1×7d及40mg·kg^-1·d^-1×7d,配对联用。统计各组的生命延长率（ILS）;电镜观察荷瘤鼠垂死前的心肌毒性表现。结果:联合用药组的ILS分别为48.7％,57.3％,59.0％和62.4％,是Sob和Dox单药应用ILS之和的130％—190％,荷瘤鼠心肌细胞的超微结构损伤较单用Dox组明显减轻。结论:Sob与Dox联用对小鼠白血病P388有显著的抑瘤协同作用;Sob能降低Dox所致的心肌毒性。更多还原

【Abstract】 AIM: To study the antitumor activity of sobu-zoxane (Sob) in combination with doxorubicin (Dox) and the effect of Sob on Dox-induced car-diotoxicity. METHODS: DBA/2 mice bearing transplanted leukemia P388 were given iv Dox 2 mg·kg-1·d-1 for 3 d, 4 mg·kg-1·d-1 for 1 d combined with ig Sob 20, 40 mg·kg-1·d-1 for 7 d. The increase in life span (ILS) of each group was recorded in 30 d. The myocardium of moribund mice was examined by transmission electron microscopy. RESULTS: The ILS of combination therapeutic groups of Sob with Dox was 48. 7 % , 57.3 %, 59.0 %, and 62.4 % respectively, which were 30 % - 90 % higher than the sum of ILS of two groups treated with Dox and Sob separately (P<0. 01). The ultrastructural injury of cardiomyocytes of P388-bearing mice caused by combination chemotherapy with Dox plus Sob was markedly attenuated compared with Dox alone. CONCLUSION: Sob with Dox exhibited an antitumor synergistic effect on leukemia P388, and the cardiotoxicity of Dox was reduced by Sob.更多还原