【摘要】 目的研究乳腺疾病针吸细胞学标本雌激素受体（ＥＲ）、孕激素受体（ＰＲ）表达的应用价值。方法采用酶联亲和组织化学法检测２００例乳腺病的ＥＲ和ＰＲ表达情况。结果在良、恶性乳腺疾病中，ＥＲ的表达无显著差异（６３．５％和６０．２％，Ｐ＞０．０５），ＰＲ的表达则有显著差异（５７．９％和４７．３％，ＰＭ＜０．０５）。乳腺病患者绝经前后ＥＲ、ＰＲ表达无显著差异（Ｐ＞０．０５）。伴有局部淋巴结转移的乳腺癌患者，ＥＲ和ＰＲ表达率明显低于无淋巴结转移者（Ｐ＜０．００１）。结论针吸细胞学标本酶联亲和组织化学法检测ＥＲ和ＰＲ表达，可以帮助判断有淋巴结转移的乳腺癌患者的预后和指导内分泌治疗。更多还原

【Abstract】 To study the value of expression of estrogen receptor (ER) and progesterone receptor (PR) on samples of needle aspiration in breast diseases.METHODS Enzyme-linked histochemical detection of expression of ER and PR was investigated in 200 cases of breast disease.RESULTS Positive rate of PR was significantly higher in benign breast diseases (57.9% )than in the malignant ones (47.3%, P<0.05), without significant differences for ER for both groups (63.5%, 60.2%,P>0.05). Neither was there a significant difference between pre-menopausal and post-menopausal patients with breast carclnoma. However,positive rates of ER and PR were both significantly lower in breast carcinomas with local lymphatic metastasis than in those without local lymphatic metastasis (P<0.05).CONCLUSIONS The detection of expression of ER and PR by using enzyme-liked histochemical methods on samples of needle aspiration might be helpful in evaluating the prognosis and endocrine therapy in breast carcinoma cases with lymphatic metastases.更多还原