【摘要】 本实验选用Ｗｉｓｔａｒ大鼠，复制创伤性休克的动物模型，观察致伤机体体内脂质过氧化物含量和纤维结合蛋白水平的变化以及地塞米松对创伤性休克的治疗作用。结果显示，大鼠致伤后１２０ｍｉｎ血浆ＭＤＡ含量即明显增加，而血浆纤维结合蛋白水平则明显降低；若使用地塞米松治疗，可使致伤后的血流动力学变化大为改善，同时体内的脂质过氧化反应也明显减轻，提示地塞米松能够抑制创伤后的脂质过氧化反应，对创伤性休克有一定的防治作用。更多还原

【Abstract】 Changes of plasma and tissue MDA(malondialdehyde)as well as plasma Fn werestudiedi in traumatic shock models of Wistar rats. Obviously increased of plasma and tissue MDAand decreased Fn(fibronectin) were observed 120 minutes after the set up of tnluma. Intervention ofdexamethason bolus(20mg ·kg-1·5ml-1,Ns)showed prominent effed against lipid peroxidation andhemodynamic change.更多还原