【摘要】 本文应用指示剂稀释技术观察了家兔ＳＭＡＰＯ休克时肺对￣（１２５）Ｉ标记的Ｐ物质（￣（１２５）－ＳＰ）和血管活性肠肽（￣（１２５）Ｉ－ＶＩＰ）的清除作用。结果表明，ＳＭＡＯ休克早期注入ＳＰ（ｌｐｍｏｌ／ｋｇ）一次流经肺循环的清除率（３５．０１±０．６４％）明显高于假手术对照组（２２．９６±２．２２％），Ｐ＜０．０１，注入ＶＩＰ（１．５ｐｍｏｌ／ｋｇ）一次流经肺循环的清除率（３７．８９±２．３０％），与假手术对照组（３８．５０±２２９％）相比无显著性差异。本实验结果证明家兔肺具有清除循环血中ＳＰ和ＶＩＰ的作用。休克时肺加强清除ＳＰ可能具有代偿意义。更多还原

【Abstract】 An indicator dilution method was used to measuxe the clearance of￣(125)I-SP and ￣(125)-I-VIP when they once passed through the lung in SMAO shock mb-bits. In the early stage of shock the clearance of SP by lung (35.01± 0.64%,n=6)washigher than shamopemted control (22.96± 2.22%,n=7) , P<0.e1; but no difference was ob-served in the clearance of VIP by lung between SMAO shock group (37.89± 2.30%,n=5)and control group(38.50±2.29%, n=5).This study showed that both SP and VIPcan be cleared by rabbit lung.The increased clearance of SP during early stage ofSMAO shock may have some effect for delaying the blood pressure declining.更多还原