【摘要】 测定了８名受试者ｐｏ吉非贝齐（Ｇｅｍ）６００ｍｇ后血药浓度一时间数据，观察到血药浓度双峰现象。建立一种双部位吸收药动学模型拟合这些数据，实验值与拟合值吻合好，ｒ￣２均大于０．９９。相应参数如下：Ｔ＿（ｍａｘ１）１．１０±０．４６ｈ；Ｔ＿（ｍａｘ２）２．６０±０．７３ｈ；Ｃ＿（ｍａｘ１）１３．６２±４．３μｇ·ｍｌ￣（－１）；Ｃ＿（ｍａｘ２）１７．２２±３．８３μｇ·ｍｌ￣（－１）；Ｔ＿１０．０６±０．０６ｈ；Ｔ＿２１．４２±０．５７ｈ；Ｔ＿３１．７９±０．６０ｈ更多还原

【Abstract】 The plasma concentration-time data of gemfibrozil in 8 male subjects weredetermined after an oral dose of 600 mg.Two-peak concentrations in plasma were observed.A kind ofone-compartment model with two-sites of drug absorption was proposed and used to fit these data。Agood agreement between observed and predicted data was found in all subjects with correlation indexes(γ2)>0.99.The corresponding pharmacokinetic parameters were estimated as follows:Tmax1,1.10±0.46h;Tmax2,2.60±0.73h;Cmax1,13.62±4.30μg·ml-1;Cmax2,17.22±3.83μg·ml-1;T1,0.06±0.06h,1.42±0.57h and T3,1.79±0.60 h.更多还原